Research Results of Team of Associate Professor Yongping Bai, Department of Geriatric Medicine, Xiangya Hospital, Central South University is Published in Science
2019/2/1 16:57:49
Source: Department of Geriatric Medicine    Author:     Clicks: 28

Recently, the research group led byYongping Bai, an associate professor in the Department of Geriatric Medicine, Xiangya Hospital, Central South University, has made significant progress in the study of the mechanism of atherosclerosis by working with the team led by Longhou Fang, an associate professor in the Center for Cardiovascular Regeneration, Houston Methodist in the United States. Their research result has been published in the top academic journal Science (IF: 41.058) in the form of report entitled “AIBP-mediated Cholesterol Efflux Instructions Hematopoietic Stem and Progenitor Cell Fate”. Associate Professor Kaifu Chen, Associate Professor Yongping Bai and Associate Professor Longhou Fang are co-corresponding authors.

Hypercholesterolemia is an important driving factor in the occurrence and development of atherosclerosis and promotes the proliferation of hematopoietic stem and progenitor cells (HSPCs) during atherosclerosis. However, the relationship and mechanisms between hypercholesterolemia and hematopoietic function are unclear. In the research, the researchers first observed that elevated plasma cholesterol levels activated endothelial cell SREBP2 and activated hemogenic endothelium in conjunction with Notch1 signaling pathway, thereby promoting the proliferation and mobilization of HSPC and release of inflammatory factors, and promoting the development of atherosclerosis. Subsequently, the researchers identified the key regulatory role of a specific apolipoprotein binding protein AIBP between SREP2 and Notch1 signaling pathways through a variety of techniques.

The result systematically elaborates the specific molecular mechanism associated with hyperlipidemia and hematopoiesis, and reveals the regulatory role of AIBP in hemogenic endothelium hematopoiesis and its specific impact in atherosclerotic diseases through the above two pathways, which provides a new entry point for the prevention and treatment of clinical atherosclerotic diseases.

It is reported that under the guidance of Prof. Guogang Zhang , Associate Professor YongpingBai has been focusing on the prevention and treatment of coronary heart disease. He and his team members have published a number of research results in top international journals and trained many outstanding professionals. In addition, the team maintains long-term and stable cooperative relations with many top laboratories in China and the United States. They promote development and improvement in each other through mutual visits and joint training of students.

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