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Team of Professor Lei Guanghua Published an Original Article Based on Xiangya Osteoarthritis Study in Arthritis & Rheumatology


Recently, team of Professor Lei Guanghua from the Department of Orthopaedics of Xiangya Hospital, Central South University/National Clinical Research Center for Geriatric Disorders made great achievements in the field of clinical prevention and treatment of osteoarthritis, and published an original article titled Association Between Gut Microbiota and Symptomatic Hand Osteoarthritis: Data From the Xiangya Osteoarthritis Study in the top professional journal Arthritis & Rheumatology (IF: 10.995). Associate researcher Wei Jie from the Health Management Center of Xiangya Hospital, Central South University and the Hunan Key Laboratory of Bone Joint Degeneration and Injury is the first author. Professor Lei Guanghua and Professor Zeng Chao are the corresponding authors. Xiangya Hospital, Central South University is the first affiliation and the only corresponding affiliation. The study was funded by the Key Clinical Research Project of the National Clinical Research Center for Geriatric Disorders and the National Natural Science Foundation of China (NSFC).

Hand osteoarthritis exhibits a high prevalence rate, with a prevalence rate of 18-47% in primary hand osteoarthritis in people aged 40 years old and above in China, and its chronic pain symptoms severely affect the quality of life. However, its pathogenesis has not yet been elucidated, and there is a lack of safe and effective therapies at present. In this study, the association between alteration of gut microbiota and prevalence of hand osteoarthritis was explored for the first time based on the Xiangya Osteoarthritis study, internationally named Xiangya Osteoarthritis (XO) Study, a prospective and stably followed-up natural population cohort study with a large sample size. Besides, the bacterial genus playing a key role in it and relevant metabolic pathways were clarified, which offers new insights for further elucidation of the pathogenesis of hand osteoarthritis and a theoretical basis for subsequent exploration of new targets for its prevention and treatment.

The team led by Professor Lei Guanghua has been committed to studying the pathogenesis, clinical prevention and treatment, and translational medicine of degenerative joint diseases. Professor Lei is selected as the leading talent of the national "Ten-thousand Talents Program" and the distinguished professor of "Changjiang Scholars Program" of the Ministry of Education, and awarded the "National Advanced Worker". In recent years, he has been in charge of 5 projects of NSFC (including 1 key project) and 1 project of national key research and development plan. Besides, he has published more than 140 SCI papers in JAMA, New Engl J Med, Ann Intern Med, Ann Rheum Dis, Br J Sports Med, Nat Commun, Arthritis & Rheumatology and other journals as the corresponding author. The total IF of these SCI papers is 900+, with the highest IF of 56.272 for a single original article. The research results have been included into the clinical guidelines of authoritative academic organizations such as the European League Against Rheumatism, American College of Rheumatology, French Society for Rheumatology, and German Pain Society 18 times. In addition, he has edited the publication of 5 clinical diagnosis and treatment guidelines and expert consensuses of Chinese Medical Association. Moreover, he has obtained authorization for 34 patents. Additionally, he serves as the reviewer for over 50 SCI journals including BMJ and Arthritis & Rheumatology and has won the first prize of the Science and Technology Progress Award of Ministry of Education and the first prize of Huaxia Medical Science and Technology Award.

Wei Jie, an associate researcher of the Health Management Center of Xiangya Hospital, a doctor in epidemiology and health statistics, and a postdoctoral fellow of Massachusetts General Hospital, Harvard University, is now the deputy director of Hunan Key Laboratory of Bone Joint Degeneration and Injury, mainly engaged in clinical research on osteoarthritis. He has been in charge of 1 project of NSFC and published 22 SCI papers in renowned journals such as Arthritis & Rheumatology (IF: 10.995), Br J Sports Med (IF: 13.800), J Bone Miner Res, Osteoarthritis Cartilage, Bone and Arthroscopy as the first or corresponding author (including co-first or co-corresponding author) in recent years.

For PIs and postdoctoral fellows in the fields of "bioinformation", "osteoarthritis", "sarcopenia" and "pain" who would like to join the team of Professor Lei Guanghua, please send emails to lei_guanghua@csu.edu.cn for further communication.

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