The research team led by Professor Qi Min from Department of Plastic and Cosmetic Surgery, Xiangya Hospital, Central South University, has worked out important achievements in exploring the occurrence and development of breast cancer in cooperation with the team of Professor Huang Lei from Shanghai Jiao Tong University College of Basic Medical Sciences. The results titled WWP1 targeting MUC1 for ubiquitin-mediated lysosomal degradation to suppress carcinogenesis were published on August 18, 2021 as an original research letter in SIGNAL TRANSDUCTTAR (IF: 18.187), a sub-journal of Nature and the leading journal in the Excellence Action Plan of China STM Journals. Prof. Qi is the co-corresponding author, and Yu Liping, a graduate student from the Department of Plastic Surgery is the second author. This study revealed, for the first time, that WWP1 triggers MUC1 degradation through ubiquitin-mediated lysosomal pathway.
Breast cancer ranks first among the cancers to which females are susceptible, and Mucin1 is deemed as an important factor driving the development of breast cancer. How to degrade Mucin1 in an efficient and safe manner is a problem to be settled urgently. This study first observed that there was a significant inverse correlation between Mucin1 and WWP1 proteins in breast cancer, and revealed that WWP1 promoted the ubiquitination of MUC1 and degraded MUC1 through the lysosomal pathway, thereby inhibiting the development of breast cancer. This achievement systematically demonstrated the specific molecular mechanism of the carcinogenic factor MUC1 degradation by WWP1 proteins in breast cancer, providing a novel strategy for the R&D of clinical targeted drugs for breast cancer.
The research group of Prof. Qi and the team of Prof. Huang have maintained long-term and stable cooperation in terms of technology sharing and joint student training to exchange experience and make common progress.
Xiangya Hospital Central South University
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