Circulation Publishes the Latest Research Results of Prof. Zhang Guogang’s Team of Xiangya Hospital
2018/2/12 11:46:36
Source: Cardiology    Author:     Clicks: 

The international top medical journal Circulation (IF=19.309) has published online the latest research results of Prof. Zhang Guogang’s team of Xiangya Hospital in the mechanism of nitroglycerin. The findings of the study reveal the new mechanism of epigenetic regulation of nitroglycerin tolerance for the first time and are expected to provide a new breakthrough for the prevention and reversal of nitroglycerin tolerance.


Circulation Publishes Online the Latest Research Result of Prof. Zhang Guogang’s Team of Xiangya Hospital

This paper published online is entitled “Induction of microRNA-199 by Nitric Oxide in Endothelial Cells is Required for Nitrovasodilator Resistance via Targeting of Prostaglandin I2 Synthase”. Its first author is Associate Professor Bai Yongping from the Department of Geriatric Cardiology and its correspondence author is Prof. Zhang Guozhang from the Department of Cardiovascular Medicine. Affiliation of both the first and corresponding authors is Xiangya Hospital, Central South University.

Nitroglycerin is a classic anti-myocardial ischemia drug. It has been used for 150 years in clinical practice, and it is the first choice for emergency treatment of patients with coronary heart disease because of its fast onset and remarkable effect. However, drug tolerance occurs after continuous use of 24 to 48 hours, which greatly restricts its long-term effect. Therefore, to study the mechanism of nitroglycerin tolerance and find intervention measures has been one of the urgent problems that need to be solved in the field of cardiovascular research for a long time.

Prof. Zhang Guogang’s research team took the lead to introduce the theory and technology of epigenetics into the nitroglycerin tolerance study and use the classic nitroglycerin tolerance model combined with clinical and cytological evidence to reveal that the inactivation of prostacyclin synthase (PTGIS) caused by abnormal increase of microRNA-199 is the key mechanism for nitroglycerin tolerance and that indomethacin, iloprost and SQ29548 can reverse nitroglycerin tolerance. The findings not only provide a new explanation for the nitroglycerin tolerance, but also provide a feasible treatment for reversing nitroglycerin tolerance.

Founded in 1950, Circulation is the leading professional journal in the cardiovascular field. Its manuscript acceptance rate is very low and it only publishes high level research results. Prof. Joseph A. Hill, Chief Editor of Circulation, thinks highly of this paper, “This evidence provided suggests that NO-mediated induction of miR-199a/b in endothelial cells serves as a key mechanism for nitrate tolerance.”

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