Hunan Key Laboratory for Skin Tumor and Psoriasis Publishes Mutiple Papers on World’s Major Journals
2018/1/19 22:03:54
Source: Hunan Key Laboratory for Skin Tumor and Psoriasis    Author:     Clicks: 

Good news came from Nature Communication today that a paper from Hunan Key Laboratory for Skin Tumor and Psoriasis was published on this journal. This is another achievement of the laboratory since it launched a major international cooperation project of the National Natural Science Foundation of China. Since 2017, the laboratory has worked with top overseas research institutes to look into difficult and frequently encountered issues in oncological research from multiple perspectives and published a number of papers, proving its international cooperation is fruitful. 



In January 2018, Distinguished Visiting Professor Cui Rutao and Prof. Chen Xiang, director of the laboratory, who are both corresponding authors of this paper, guided young scholar Chen Shuyang, who is a specially–appointed researcher of the laboratory, revealed that histone H3K79 methyltransferase DOT1L expressed by melanocyte is able to inhibit development of UVR-induced melanoma and expounded the interrelationship between UVR and skin pigment diseases and melanoma. The finding will be published on Natural Communication (2018) 9:259 in January 2018. The journal is run by Nature Publishing Group with an Impact Factor (IF) of 12.124 in 2017. 



Moreover, the laboratory published articles by collaborating with prestigious foreign research institutes. Based on the pathogenesy of melanoma, Cui Rutao has enunciated for the first time that protein palmitoylation mediated by protein-acyltransferase ZDHHC13 is capable of recovering the function of mutant MC1R, providing new strategies for eliminating high melanoma risk caused by MC1R mutation and for the practice of preventing and curing melanoma. This finding has made its way to Nature (2017,549 (7672): 399-403) of September 2017. Nature is one of the world’s oldest international scientific and technological journals. Since its first issue in 1869, it covers the most significant findings and breakthroughs in global realm of science and technology. It is highly influential with current IF being 40.137. 



Invasion and metastasis of malignant tumor is the main cause of death. Prof. Peng Cong, deputy director of the laboratory, has cooperated with Prof. Dong Zigang from University of Minnesota to clarify the new function of protein kinase RSK2 in the invasion and metastasis of tumor cell. This molecule prevents invasion and metastasis of cancer cell by modifying and boosting the secretion of INF-γ and adjusting organism immunity. This finding shed new light on invasion and metastasis of malignant tumor, and was published on PNAS (2017; 114 (48): 12791-12796) dated November 28, 2017. PNAS is a journal of National Academy of Sciences and is widely acknowledged to be one of the world’s four most famous journals (the other three are Cell, Nature and Science). As a classic journal that has been circulated for more than 100 years, it boasts far-reaching international influence, with current IF being 9.661. 

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